Informace o projektu
Next Generation Sequencing Platform for Targeted Personalized Therapy of Leukemia
(NGS-PTL)
- Kód projektu
- 7E13008
- Období řešení
- 9/2013 - 10/2015
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Podpora projektů sedmého rámcového programu Evropského společenství pro výzkum, technologický rozvoj a demonstrace (2007 až 2013)
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
This project aims at developing a European Hematological/HTS platform of scientists for improving outcomes for therapeutic interventions on acute and chronic leukemias and at develop strategies to personalize treatments and tailor therapies to different stratified groups of leukemia patients, with the goal of optimizing their efficacy and safety through a deeper and deeper understanding of the influence of genetic/genomic alterations on leukemias pathogenesis and treatment response (i.e. “personalized therapy”). Moreover, the final aim will be the identification of novel prognostic biomarkers for acute and chronic leukemias, as well as of molecular biomarkers and/or genomic profiles for the assessment of minimal residual disease. The originality of this project is to perform systematic deep genomic/transcriptomic studies on well-clinically-characterized leukemia patients, by exploiting HTS technologies able to quickly produce data with a good cost-effectiveness and an unprecedented resolution.
Publikace
Počet publikací: 23
2015
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Functional loss of I kappa B epsilon leads to NF-kappa B deregulation in aggressive chronic lymphocytic leukemia
The Journal of Experimental Medicine, rok: 2015, ročník: 212, vydání: 6, DOI
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MicroRNAs in B cell lymphomas: how a complex biology gets more complex
Leukemia, rok: 2015, ročník: 29, vydání: 5, DOI
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Mutations in the TP53 gene show features of somatic hypermutation process with prominent difference between IGHV mutated and unmutated chronic lymphocytic leukemia
Rok: 2015, druh: Konferenční abstrakty
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Recurrent mutations refine prognosis in chronic lymphocytic leukemia.
Leukemia, rok: 2015, ročník: 29, vydání: 2, DOI
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Separation of residual malignant cells from peripheral blood of treated patients with chronic lymphocytic leukemia
Rok: 2015, druh: Konferenční abstrakty
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation within a clinical setting
Haematologica, rok: 2015, ročník: 100, vydání: 3, DOI
2014
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Biological and clinical relevance of mirnas induced in chronic lymphocytic leukemia (CLL) cells during administration of therapy in vivo and in vitro
Rok: 2014, druh: Konferenční abstrakty
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Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis.
Leukemia Research, rok: 2014, ročník: 38, vydání: 2, DOI
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Deep sequencing for detailed analysis of TP53 mutations clonal evolution in chronic lymphocytic leukemia
Rok: 2014, druh: Konferenční abstrakty
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Deep sequencing for identification of minor-clone TP53 mutations before their clonal selection by therapy in chronic lmyphocytic leukemia
Rok: 2014, druh: Konferenční abstrakty