DNA as a training platform for photodynamic processes in soft materials — LightDyNAmics (LightDyNAmics)
- Kód projektu
- Období řešení
- 4/2018 - 3/2022
- Investor / Programový rámec / typ projektu
- Evropská unie
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
Centre national de la recherche scientifique
University of Durham
Politecnico di Milano
Consiglio Nazionale Delle Ricerche
LightDyNAmics network merges excellence, completeness and complementarity: it brings together 10 of Europe`s leading academic groups with first-rate scientific records and a consolidated experience in methods development to master photoactivated processes in macromolecular systems such as DNA. Their expertise covers a wealth of time-resolved spectroscopies and quantum mechanical methods, as well as the conforma-tional characterization of bio-macromolecules and their manipulation with advanced synthetic approaches. The extremely high scientific level of the industrial partners, two SME and one large Company, will contribute to the success of the research activity and will make easier technology transfer.
LightDyNAmics will develop new experimental and computational methods for the study of light/soft-matter interaction. LightDyNAmics will train 15 early stage researchers (ESRs) using a novel mix of experimental, computational and modelling skills. LightDyNAmics will elucidate the photoactivated dynamics of DNA with an unprecedented spatial and time resolution and assess many crucial issues for photodamage, paving the way to new drugs and new diagnostic tools. Our success will enable fundamental technological advances in the use of light as a powerful analytical tool to study Nucleic Acids and their interaction with proteins, drugs, or other molecules with very high spatial and time resolution. Companies will exploit these advances in three cutting-edge applications.