Informace o projektu
The effect of transcranial direct current stimulation on visual attention in mild cognitive impairment – a combined fMRI and non-invasive brain stimulation study
- Kód projektu
- NV18-04-00256
- Období řešení
- 5/2018 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo zdravotnictví ČR
- Program na podporu zdravotnického aplikovaného výzkumu a vývoje na léta 2015 - 2022
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Fakultní nemocnice U sv. Anny Brno
- Odpovědná osoba prof. MUDr. Irena Rektorová, Ph.D.
Alzheimer’s disease (AD) is the most common neurodegenerative disease that progressively causes the breakdown of cognitive functions. From the disease onset, particularly semantic memory and spatial orientation have been affected. However, various aspects of visual dysfunctions have also been identified early in the course of the disease (Rizzo et al., 2000) affecting both lower-level vision (Valenti, 2010), e.g. nerve fiber deficits; lens opacities; functional losses in the magnocellular pathway and higher-level vision (Jacobs et al., 2012b; Rizzo et al., 2000), e.g. visual perception, visual working memory and visual attention (Krajčovičová et al., 2014a).
Recent research has been focused particularly on mild cognitive impairment due to Alzheimer’s disease (MCI-AD), i.e. the transitional stage between normal aging and dementia (Petersen, Negash, 2008, Albert, 2011). Since there is no pharmacological treatment available for MCI-AD an increased attention has been drawn to non-pharmacological interventions such as non-invasive brain stimulation techniques (NBIS), including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) (e.g. Anderkova and Rektorova, 2014; Boggio et al., 2012; Ferrucii et al., 2008; Meinzer et al., 2015). TDCS represents a promising tool for modulating cognitive functions in physiological and pathological aging (Hsu et al., 2015) with practical potential because it is safe (Bikson et al., 2016), well tolerated (Kessler et al., 2012) and relatively affordable compared to other NBIS techniques.
The current study will combine MRI and tDCS techniques to investigate both specific stimulation-induced effects on attentional visual processing in MCI-AD patients as compared to age-matched healthy controls (HC) and neural correlates of these changes in both groups.
Publikace
Počet publikací: 8
2024
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Exploring the impact of intensified multiple session tDCS over the left DLPFC on brain function in MCI: a randomized control trial.
Sci Rep, rok: 2024, vydání: 14, DOI
2022
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Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
Scientific Reports, rok: 2022, ročník: 12, vydání: 1, DOI
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Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis
Clinical Neurophysiology, rok: 2022, ročník: 144, vydání: DEC, DOI
2021
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Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors.
Neural Plasticity, rok: 2021, ročník: 2021, vydání: APR, DOI
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Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia
Clinical Neurophysiology, rok: 2021, ročník: 132, vydání: 10, DOI
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Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network
Neural Plasticity, rok: 2021, ročník: 2021, vydání: July 2021, DOI
2020
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Non-pharmacological management of cognitive impairment in Parkinson’s disease
Journal of Neural Transmission, rok: 2020, ročník: 127, vydání: 5, DOI
2018
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Neinvazivní mozková stimulace v behaviorální a kognitivní neurologii.
Neurologie pro praxi, rok: 2018, ročník: 19, vydání: 6