Informace o projektu
Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia: a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease progress
- Kód projektu
- NV19-03-00091
- Období řešení
- 5/2019 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo zdravotnictví ČR
- Program na podporu zdravotnického aplikovaného výzkumu a vývoje na léta 2015 - 2022
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Fakultní nemocnice Brno
- Odpovědná osoba Mgr. Veronika Navrkalová, Ph.D.
Chronic lymphocytic leukemia (CLL) is common and still incurable leukemia of adults characterized by remarkable genetic and clinical heterogeneity. In proposed project we aim to study genetic background underlying clonal evolution of genomic alterations in treatment naïve CLL patients taking the advantage of availability of consecutive samples collected during disease course. Our main objective is to early disclose the disease progression and therapy need. We plan to assess both the prognostic and the predictive value of genomic aberrations detected just before treatment start. For this purpose, a highly complex next-generation sequencing (NGS) tool analyzing simultaneously both fundamental, as well as novel CLL biomarkers will be implemented. We employ benefits of capture-based NGS technology enabling to analyze in one test IGHV mutational status, recurrent chromosomal and gene defects, and Ig light chains clonality. We presume that our NGS panel tailored for CLL can be widely adopted in clinical practice as a simple comprehensive test for better patient prognostication.
Publikace
Počet publikací: 48
2022
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Současná role cytogenomiky v diagnostice a prognostické stratifikaci hematologických malignit.
Rok: 2022, druh: Konferenční abstrakty
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Subclonal architectureof chromosomes revealed by single-cell analysis of gene expression in a patient with clonal evolution of relapsing/refractory CLL
Rok: 2022, druh: Konferenční abstrakty
2021
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A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
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Bioinformatic strategies for the analysis of genomic aberrations detected by targeted NGS panels with clinical application
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Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study
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Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
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Dynamika mutací a chromozomálních aberací v závislosti na aktivitě CLL u neléčených pacientů.
Rok: 2021, druh: Konferenční abstrakty
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Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on BCR-ABL1-like subtype
Acta Oncologica, rok: 2021, ročník: 60, vydání: 6, DOI
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Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL
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Klinický dopad a evoluce minoritních TP53-mutovaných klonů v kontextu různých terapeutických režimů u CLL.
Rok: 2021, druh: Konferenční abstrakty