Informace o projektu

Genome-wide integrative analysis of DNA methylation and transcriptional expression of different lineages of Treponema pallidum subsp. pallidum, the causative agents of syphilis

Kód projektu
MUNI/11/SUP/04/2020
Období řešení
10/2020 - 1/2021
Investor / Programový rámec / typ projektu
Masarykova univerzita
Fakulta / Pracoviště MU
Lékařská fakulta

Syphilis, caused by the bacterium Treponema pallidum subsp. pallidum (TPA) is considered a re-emerging disease with over 5.6 million cases worldwide. Despite causing severe life-threatening infections, very little is known about the basic biology of TPA. The goal of this research proposal is to link in vitro and in vivo cultivation to genomic approaches to provide unique insights into the gene expression and epigenetic profiles of this pathogen. We will characterize differential transcriptomic responses of TPA and characterize how the transcriptomic responses correlate with the DNA methylation pattern. This should provide valuable information for the understanding of the basic biology of pathogenic treponemes that has not been previously studied.