Informace o projektu

Crosstalk between energy-sensing pathways in melanoma (Crosstalk between energy-sensing pathways)

Kód projektu
MUNI/IGA/1113/2021
Období řešení
1/2022 - 12/2022
Investor / Programový rámec / typ projektu
Masarykova univerzita
Fakulta / Pracoviště MU
Lékařská fakulta

Melanoma is commonly driven by oncogenic mutations over-activating the ERK signalling pathway. We found that metabolic stress can affect ERK activity in melanoma, through the AMPK kinase. Crucially, we observed decreased AMPK activation in cells with a disrupted lysosomal Ragulator complex. This project aims to determine the role of Ragulator in the crosstalk between ERK and nutrient-sensing pathways AMPK and mTORC1 in melanoma. Our findings could lead to new therapeutic strategies for melanoma.

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