Informace o projektu
Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe
(ADDIT-CE)
- Kód projektu
- 101087124
- Období řešení
- 1/2023 - 12/2026
- Investor / Programový rámec / typ projektu
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Evropská unie
- Horizont Evropa
- Rozšiřování účasti a posílení ERA
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Další fakulta/pracoviště MU
- Lékařská fakulta
- Další fakulta/pracoviště MU
- Přírodovědecká fakulta
- WWW stránky projektu
- https://addit-ce.ceitec.cz/
- Spolupracující organizace
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Fakultní nemocnice U sv. Anny Brno
- Odpovědná osoba Katerina Sheardova
- Odpovědná osoba Mgr. Veronika Štěpánková, Ph.D.
- Odpovědná osoba Barbara Ukropcova
- Odpovědná osoba Norbert Žilka
Ministerstvo zdravotníctva Slovenskej Republiky
MultiplexDX
- Odpovědná osoba Adrián Szobi
- Odpovědná osoba Tomas Szemes
Česká alzheimerovská společnost, o.p.s.
- Odpovědná osoba Martina Mátlová
Dementia represents unmet medical need, more than 55 million of people suffer from this fatal disorder. Currently, there is no effective disease modifying therapy. Early diagnosis can significantly reduce total costs. Currently, there is no conceptual plan which would implement the modern diagnostic approaches into the clinical practise in Czech and Slovak republic. The interaction between universities and private sectors leading to the development of molecular diagnostic tools is fragmented and not properly organised. Limited number of talented students are interested in applied neuroscience research focusing on dementia. The main aim of the project is to create two inter-linked ecosystems, in Moravia and Bratislava region, which will encompass the whole quadruple helix of innovation driving actors: excellent scientific teams from Masaryk University and Slovak Academy of Sciences will collaborate with private biotech companies. The societal actors will be represented by organisations such as Slovak Alzheimer´s Society, Czech Alzheimer´s society, Centrum Memory and Czech Brain Aging Study. The regional government will be involved through Ministry of Health Slovak Republic, and South Moravian Innovation Centre. The interconnected ecosystems will unite the research and innovation activities focusing on new diagnostic methods and their applications and further interlink academia and business spheres by creating a pilot programme of industrial PhD positions for talented students. The project will generate a joint cross-border strategy covering basic and applied research activities in the field of Alzheimer Disease diagnostics, transfer new cutting-edge technologies into the clinical practise, and accelerate the development of new diagnostic tools for AD diagnostics. The project will join forces of all actors of the involved ecosystems to revolutionise the diagnostic approaches in both countries.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 13
2024
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A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single-cell suspension
Biotechnology Journal, rok: 2024, ročník: 19, vydání: 8, DOI
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Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer's Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control
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Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3zeta protein variants
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, rok: 2024, ročník: 266, vydání: Pt 2, DOI
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How does phosphorylation affect interaction between 14-3-3ζ and Tau proteins?
Rok: 2024, druh: Konferenční abstrakty
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Preparation of Alzheimer's-disease-relevant Tau protein in HEK293 mammalian cells
Rok: 2024, druh: Konferenční abstrakty
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The effect of phosphoserine 324 on the paired helical filaments of tau protein
Rok: 2024, druh: Konferenční abstrakty
2023
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14-3-3 dimer vs monomer – (dis)similarities in Tau protein binding
Rok: 2023, druh: Konferenční abstrakty
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Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development
CELL REPORTS, rok: 2023, ročník: 42, vydání: 11, DOI
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Conformational changes upon phosphorylation of proline rich region of tau(210-240) peptide using molecular dynamic simulation
Rok: 2023, druh: Konferenční abstrakty
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Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues
ChemCatChem, rok: 2023, ročník: 15, vydání: 19, DOI