Informace o publikaci

MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis

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NOVÁK Jan VINKLÁREK Jan BIENERTOVÁ VAŠKŮ Julie SLABÝ Ondřej

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj PEDIATRIC BLOOD & CANCER
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://onlinelibrary.wiley.com/doi/10.1002/pbc.24664/pdf
Doi http://dx.doi.org/10.1002/pbc.24664
Obor Fyziologie
Klíčová slova microRNA; myogenesis; myomirs; rhabdomyosarcoma
Přiložené soubory
Popis MicroRNAs (miRs) are small non-coding RNAs known to fulfill various functions in tissue development, function, and pathogenesis of various diseases, including cancer. Rhabdomyosarcoma (RMS) represents the most common soft tissue tumor in the pediatric population. miRs have been shown to play important roles in RMS pathogenesis and some of the studies suggest their potential as diagnostic, prognostic, and even therapeutic tools facilitating better management of this disease. This review summarizes current information about the role of miRs in the development of normal skeletal muscle and their deregulation in RMS.

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