Informace o publikaci

Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture

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BÁRTA Tomáš DOLEŽALOVÁ Dáša HOLUBCOVÁ Zuzana HAMPL Aleš

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Experimental Biology and Medicine
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1177/1535370213480711
Obor Genetika a molekulární biologie
Klíčová slova human embryonic stem cells; cell cycle; culture adaptation; long-term culture
Přiložené soubory
Popis Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
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