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Patient with inoperable pheochromocytoma

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BRANČÍKOVÁ Dagmar MECHL Zdeněk ADAM Zdeněk JANDÁKOVÁ Eva PAVLOVSKÝ Zdeněk VÁLEK Vlastimil ANDRAŠINA Tomáš

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Current Oncology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.3747/co.22.2324
Obor Onkologie a hematologie
Klíčová slova Pheochromocytoma; chemoembolization; lanreotide
Popis Malignant pheochromocytoma is a tumour with a very low incidence that occurs sporadically or in the presence of multiple endocrine neoplasia. We present the case of a woman with a sporadic occurrence of pheochromocytoma diagnosed in the phase of multiple dissemination in the abdominal cavity and overexpressing adrenaline, noradrenaline, and dopamine. Local transarterial chemoembolization and systemic treatment with lanreotide resulted in a very good response, a decrease in the production of catecholamines for 12 months and a partial decrease for another 8 months, with stabilization of disease determined by imaging. Systemic treatment with tegafur resulted in disease stabilization lasting 50 months, after which the drug was discontinued because of adverse effects. Maintenance therapy with lanreotide continues, and no disease progression has been observed for 4 months. The treatment algorithm for such patients is multidisciplinary and must always take into account the current scope of the disease, intercurrence, and the general condition of the patient.

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