Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.
|Druh||Článek ve sborníku|
|Konference||Measurement 2015 : Proceedings of the 10th International Conference on Measurement|
|Fakulta / Pracoviště MU|
|Obor||Farmakologie a lékárnická chemie|
|Klíčová slova||ASL; schizophrenia; poly I:C animal model; rats; aripiprazole|
|Popis||Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.|