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Calcium versus strontium handling by the heart muscle

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HENDRYCH Michal OLEJNÍČKOVÁ Veronika NOVÁKOVÁ Marie

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj General Physiology and Biophysics
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Fyziologie
Klíčová slova strontium; calcium; cardiomyocyte; sarcoplasmatic reticulum; mitochondria
Popis Calcium plays a crucial role in numerous processes in living systems, from both intracellular and intercellular signalling to blood clotting. Calcium can be replaced by strontium in various intracellular processes due to high level of their similarity and strontium thus may serve as a valuable tool for different experimental studies. On the other hand, strontium is also used in clinical medicine and is commonly taken to the human body with food and water. The negative cardiac side effects of strontium therapy of osteoporosis and bone metastases are well known, but still not fully explained. This fact explains enhanced interest in this element and its impact on human body. This article reviews effects of calcium and strontium on several biochemical and physiological processes, with special emphasis on cardiac muscle.
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