Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

• Autoři: COSTAS L.; INFANTE-RIVARD C.; ZOCK J.P.; VAN TONGEREN M.; BOFFETTA P.; CUSSON A.; ROBLES C.; CASABONNE D.; BENAVENTE Y.; BECKER N.; BRENNAN P.; FORETOVÁ Lenka; MAYNADIE M.; STAINES A.; NIETERS A.; COCCO P.; SANJOSÉ S. de
• Rok publikování: 2015
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: British journal of cancer
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: https://doi.org/10.1038/bjc.2015.83
• Obor: Onkologie a hematologie
• Klíčová slova: endocrine disruptors; chemicals; lymphoma; leukaemia; solvents; pesticides; alkylphenols
• Popis: Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend = 0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.