Informace o publikaci
The Synthesis of Two Regioisomeric Aldehydes with Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions
| Autoři | |
|---|---|
| Rok publikování | 2016 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Synthesis |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1055/s-0035-1561428 |
| Obor | Organická chemie |
| Klíčová slova | dipolar cycloadditions; benzothiophenes; polycycles; heterocycles; azomethine ylides; |
| Popis | The paper describes synthesis of two regioisomeric 2-amino-3-formyl and 3-amino-2-formyl substituted derivatives of tetrahydrobenzo[b] thiophene and their preparation for subsequent thermally-initiated reactions with secondary amines for generation of azomethine ylides; these azomethine ylides entered into intramolecular 1,3-dipolar cycloadditions. In this way, two series of new fused heterocyclic compounds were prepared, having three stereogenic centres. The compounds were identified and their structures determined. |