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Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants

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PEKÁROVÁ Blanka SZMITKOWSKA Agnieszka DOPITOVÁ Radka DEGTJARIK Oksana ŽÍDEK Lukáš HEJÁTKO Jan

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Molecular Plant
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.sciencedirect.com/science/article/pii/S1674205215004517
Doi http://dx.doi.org/10.1016/j.molp.2015.11.008
Obor Biochemie
Klíčová slova multistep phosphorelay; structure; histidine kinase; phosphotransfer protein; response regulator
Popis The multistep phosphorelay (MSP) is a central signaling pathway in plants integrating a wide spectrum of hormonal and environmental inputs and controlling numerous developmental adaptations. For the thorough comprehension of the molecular mechanisms underlying the MSP-mediated signal recognition and transduction, the detailed structural characterization of individual members of the pathway is critical. In this review we describe and discuss the recently known crystal and nuclear magnetic resonance structures of proteins acting in MSP signaling in higher plants, focusing particularly on cytokinin and ethylene signaling in Arabidopsis thaliana. We discuss the range of functional aspects of available structural information including determination of ligand specificity, activation of the receptor via its autophosphorylation, and downstreamsignal transduction through the phosphorelay. We compare the plant structures with their bacterial counterparts and show that although the overall similarity is high, the differences in structural details are frequent and functionally important. Finally, we discuss emerging knowledge on molecular recognition mechanisms in the MSP, and mention the latest findings regarding structural determinants of signaling specificity in the Arabidopsis MSP that could serve as a general model of this pathway in all higher plants.
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