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The evolutionary pathway of the staphylococcal cassette chromosome element

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INDRÁKOVÁ Adéla MAŠLAŇOVÁ Ivana KOVÁČOVÁ Viera DOŠKAŘ Jiří PANTŮČEK Roman

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Biologia
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.degruyter.com/view/j/biolog.2016.71.issue-11/biolog-2016-0156/biolog-2016-0156.xml
Doi http://dx.doi.org/10.1515/biolog-2016-0156
Obor Genetika a molekulární biologie
Klíčová slova Staphylococcus; methicillin-resistant Staphylococcus aureus (MRSA); staphylococcal cassette chromosome; evolution; mobile genetic elements
Přiložené soubory
Popis The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.
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