Informace o publikaci

Neurochemical Responses to Chromatic and Achromatic Stimuli in the Human Visual Cortex

Autoři

BEDNAŘÍK Petr TKÁČ Ivan GIOVE Federico EBERLY Lynn DEELCHAND Dinesh BARRETO Felipe MANGIA Silvia

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Cerebral Blood Flow and Metabolism
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://journals.sagepub.com/doi/abs/10.1177/0271678X17695291?journalCode=jcba
Doi http://dx.doi.org/10.1177/0271678X17695291
Klíčová slova MR spectroscopy; lactate; glutamate; energy metabolism; functional MRI
Popis In the present study we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called “blobs” and “interblobs”) with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info