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Invasive aspergillosis following the heart transplantation – A case report

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GODAVA Július KREJČÍ Jan HUDE Petr OZÁBALOVÁ Eva HONEK Tomáš NĚMEC Petr TICHÝ Michal PAŽOURKOVÁ Marta ŠPINAROVÁ Lenka

Druh Článek v odborném periodiku
Časopis / Zdroj Cor et Vasa
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.crvasa.2015.12.002
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova Heart transplantation; Invasive aspergillosis; Voriconazole
Popis According to the ISHLT registry infectious complications are the leading cause of death in the first year after heart transplantation. Presented case report describes the fate of 63-year-old patient with heart failure due to coronary artery heart disease, which in March 2012, underwent a heart transplantation. In May comes with symptoms of respiratory infection. Diagnosed invasive aspergillus pneumonia, for which deployed specific treatment with voriconazole. For unsatisfactory effect enhanced by the addition of amphotericin B. Despite all the care patient a month after diagnosis dies of sepsis. A subsequent autopsy found the cause of death: abscessing necrotizing bronchopneumonia, but the surprise was the absence of fungal elements both by microscopy and cultivation.