Informace o publikaci

Experiments in Molecular Subtype Recognition Based on Histopathology Images

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BUDINSKÁ Eva BOSMAN Fred POPOVICI Vlad

Druh Článek ve sborníku
Konference 2016 IEEE 13TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI)
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7493474
Doi http://dx.doi.org/10.1109/ISBI.2016.7493474
Obor Informatika
Klíčová slova colon cancer; histopathology imaging; classification; gastrointestinal tract
Popis Molecular subtypes have been recently derived for various types of cancer, in an attempt to characterize the inter-tumoral heterogeneity. In this work we explore the possibility of constructing predictors for molecular subtypes based on histopathology images. For this, we introduce a novel 2-level bag-of-features method and we apply it to a collection of colorectal cancer samples. The resulting image features capture some relevant tumor morphology patterns and led to a classifier performing similarly to one constructed from features annotated by an expert pathologist. The significance of our results extends beyond subtype prediction since they demonstrate a possible approach to multimodal (histopathology and molecular) data mining and biomarker identification.
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