Informace o publikaci

ChannelsDB: database of biomacromolecular tunnels and pores

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PRAVDA Lukáš SEHNAL David SVOBODOVÁ VAŘEKOVÁ Radka NAVRÁTILOVÁ Veronika TOUŠEK Dominik BERKA Karel OTYEPKA Michal KOČA Jaroslav

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Nucleic Acids Research
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://dx.doi.org/10.1093/nar/gkx868
Doi http://dx.doi.org/10.1093/nar/gkx868
Obor Biochemie
Klíčová slova protein structure; protein channel; substrate channeling; tunnel; pore; MOLE; database; CYP P450; ribosome; aquaporin
Přiložené soubory
Popis ChannelsDB (http://ncbr.muni.cz/ChannelsDB) is a database providing information about the positions, geometry and physicochemical properties of channels (pores and tunnels) found within biomacromolecular structures deposited in the Protein Data Bank. Channels were deposited from two sources; from literature using manual deposition and from a software tool automatically detecting tunnels leading to the enzymatic active sites and selected cofactors, and transmembrane pores. The database stores information about geometrical features (e.g. length and radius profile along a channel) and physicochemical properties involving polarity, hydrophobicity, hydropathy, charge and mutability. The stored data are interlinked with available UniProt annotation data mapping known mutation effects to channel-lining residues. All structures with channels are displayed in a clear interactive manner, further facilitating data manipulation and interpretation. As such, ChannelsDB provides an invaluable resource for research related to deciphering the biological function of biomacromolecular channels.
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