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Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces

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TESEI Giulio HELLSTRAND Erik SANAGAVARAPU Kalyani LINSE Sara SPARR Emma VÁCHA Robert LUND Mikael

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Langmuir
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155
Doi http://dx.doi.org/10.1021/acs.langmuir.7b03155
Klíčová slova QUARTZ-CRYSTAL MICROBALANCE; ATOMIC-RESOLUTION STRUCTURE; POISSON-BOLTZMANN THEORY; AIR-WATER-INTERFACE; ALPHA-SYNUCLEIN; MONTE-CARLO; STRUCTURAL BASIS; LIPID-MEMBRANES; BETA-PEPTIDE; FIBRILS
Popis Amyloid aggregates are associated with a range of human neuro-degenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface.
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