Informace o publikaci

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

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POGORELYY M.V. ELHANATI Y. MARCOU Q. SYCHEVA A.L. KOMECH E.A. NAZAROV V.I. BRITANOVA Olga CHUDAKOV Dmitriy MAMEDOV I.Z. LEBEDEV Y.B. MORA T. WALCZAK A.M.

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj PLoS Computational Biology
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable
Doi http://dx.doi.org/10.1371/journal.pcbi.1005572
Klíčová slova CONVERGENT RECOMBINATION; IDENTICAL-TWINS; PRENATAL ORIGIN; TCR; GENERATION; DIVERSITY; NAIVE; FREQUENCY; LEUKEMIA; IMMUNITY
Popis The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive over long periods, providing the basis of the public repertoire.

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