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Malária, jej liečba a profylaxia

Název česky Malárie, její léčba a profylaxe
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KARKALÍK Šimon RUDÁ Jana

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Klinická farmakologie a farmacie
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.klinickafarmakologie.cz/artkey/far-201802-0004_Malaria_jej_liecba_a_profylaxia.php
Klíčová slova malaria; therapy; antimalarial drugs; antimalarial chemoprophylaxis; indication; contraindication
Popis Malaria is a severe parasitic disease primarily affecting the tropical zone. It is caused by the in-host life cycle phase’s developmentof protozoa from Plasmodium family. It is transmitted between humans by a vector – the mosquito from the family Anopheles. InCzech Republic as well as in other countries of Europe, it is only an imported infection that is brought here by travelers returningfrom endemic countries. Without the necessary treatment, malaria may be fatal, and therefore malaria stays a global problem. Inrecent years, artemisinin and its derivatives became prominent in successful treatment of the disease, delivered in combinationwith longer acting antimalarial drugs in the treatment of uncomplicated infections in all types of parasites with very successfulresults. Intravenously administered artesunat is also used in treatment of severe forms. Chloroquine remains important in someregions in the treatment of uncomplicated malaria caused by P. vivax, P. ovale and P. malariae, and P. knowlesi, and primachin forthe elimination of P. vivax and P. ovale hypnozoids. Antimalarial chemoprophylaxis carries significant contribution in preventionof malaria.
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