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SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL

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BENEJ Michal ZAMBO Iva BILEK Ondřej ČAPOV Ivan

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj POLISH JOURNAL OF PATHOLOGY
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.5114/pjp.2017.73931
Klíčová slova neuroendocrine tumor; malignant paraganglioma; hereditary syndromes; thyroid transcription factor 1
Popis Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.

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