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Wound healing effects after application of polyunsaturated fatty acids in rat

Název česky Změny v kvalitě hojení ran po podání nenasycených mastných kyselin u potkana
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HOKYNKOVÁ Alica WILHELM Zdeněk NOVÁKOVÁ Marie BABULA Petr STRAČINA Tibor PAULOVÁ Hana HLAVÁČOVÁ Miroslava SEDLÁČKOVÁ Miroslava

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Česká a slovenská neurologie a neurochirurgie
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.14735/amcsnn2018S29
Klíčová slova polyunsaturated fatty acids; wound healing; anti-oxidative capacity; 4-1-INE; 4-hydroxy-2-nonenal
Přiložené soubory
Popis Although mechanisms of fatty acids influence on skin wound healing has not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3:omega-6:omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.
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