Informace o publikaci
Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine
| Autoři | |
|---|---|
| Rok publikování | 2018 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Vaccine |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://dx.doi.org/10.1016/j.vaccine.2018.02.027 |
| Doi | https://doi.org/10.1016/j.vaccine.2018.02.027 |
| Klíčová slova | T cell receptor; High-throughput sequencing; TCR repertoires; Inactivated influenza vaccine |
| Popis | Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination. (C) 2018 Elsevier Ltd. All rights reserved. |