Informace o publikaci

Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients

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VRÁBEL Dávid SEDLARIKOVA Lenka BESSE Lenka ŘÍHOVÁ Lucie BEZDEKOVA Renata ALMÁŠI Martina KUBACZKOVÁ Veronika BROŽOVÁ Lucie JARKOVSKÝ Jiří PLONKOVA Hana JELINEK Tomas SANDECKA Viera STORK Martin POUR Luděk ŠEVČÍKOVÁ Sabina HAJEK Roman

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj European Journal of Haematology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ejh.13358
Doi http://dx.doi.org/10.1111/ejh.13358
Klíčová slova cell-free DNA; liquid biopsy; multiple myeloma; qPCR
Popis Objectives Progress in multiple myeloma treatment allows patients to achieve deeper responses, for which the assessment of minimal residual disease (MRD) is critical. Typically, bone marrow samples are used for this purpose; however, this approach is site-limited. Liquid biopsy represents a minimally invasive and more comprehensive technique that is not site-limited, but equally challenging. Methods While majority of current data comes from short-term studies, we present a long-term study on blood-based MRD monitoring using tumor-specific cell-free DNA detection by ASO-qPCR. One hundred and twelve patients were enrolled into the study, but long-term sampling and analysis were feasible only in 45 patients. Results We found a significant correlation of quantity of tumor-specific cell-free DNA levels with clinically meaningful events [induction therapy (P = .004); ASCT (P = .012)]. Moreover, length of cfDNA fragments is associated with better treatment response of patients. Conclusions These results support the concept of tumor-specific cell-free DNA as a prognostic marker.
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