Informace o publikaci

Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index

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BRAT Kristián SVOBODA Michal HEJDUK Karel PLUTINSKÝ Marek ZATLOUKAL Jaromir VOLAKOVA Eva POPELKOVA Patrice NOVOTNA Barbora ENGOVA Dita FRANSSEN Frits M. E. VANFLETEREN Lowie E. G. W. SPRUIT Martijn A. KOBLIZEK Vladimir

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Biomedical Papers, Olomouc: Palacky University
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php
Doi http://dx.doi.org/10.5507/bp.2020.035
Klíčová slova COPD; prognostic index; pulmonary function; mortality
Popis Objectives. The BODE (BMI, Obstruction - FEV1, Dyspnoea - mMRC, Exercise - 6-MWT) and the ADO (Age, Dyspnoea - mMRC, Obstruction - FEV1) indices are widely used prognosis assessment tools for long-term mortality prediction in COPD patients but subject to limitations for use in daily clinical practice. The aim of this research was to construct a prognostic instrument that prevents these limitations and which would serve as a complementary prognostic tool for clinical use in these patients. Methods and Participants. The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). Results. The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TLCO, to the ADO index. In a head-to-head comparison, the CADOT index showed highest c-statistic values compared to the BODE and ADO indices (0.701 vs 0.677 vs 0.644, respectively). The prognostic power was more definitive when applied to the Dutch validation (CIROCO+) cohort (0.842 vs 0.799 vs 0.825, respectively). Conclusions. The CADOT index has comparable prognostic power to the BODE and ADO indices.The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices.
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