Informace o publikaci

MAIA; Fc receptor-like 3; supersedes JUNO as IZUMO1 receptor during human fertilization

Autoři	VONDRAKOVA Jana FROLIKOVA Michaela DED Lukas CERNY Jiri POSTLEROVA Pavla PALENIKOVA Veronika SIMONIK Ondrej NAHACKA Zuzana BASUS Krystof VALASKOVA Eliska MACHAN Radek PACEY Allan HOLUBCOVÁ Zuzana KOUBEK Pavel EZROVA Zuzana PARK Soojin LIU Ruiwu PARTHA Raghavendran CLARK Nathan NEUZIL Jiri IKAWA Masahito ERICKSON Kent LAM Kit S. MOORE Harry KOMRSKOVA Katerina
Rok publikování	2022
Druh	Článek v odborném periodiku
Časopis / Zdroj	Science advances
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.science.org/doi/10.1126/sciadv.abn0047
Doi	http://dx.doi.org/10.1126/sciadv.abn0047
Klíčová slova	human fertilization; MAIA; Fc receptor-like 3; supersedes JUNO; IZUMO1
Popis	Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
Související projekty:	Národní infrastruktura pro biologické a medicínské zobrazování Modernizace národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging