Informace o publikaci

Electron beam irradiation as a straightforward way to produce tailorable non-biofouling poly(2-methyl-2-oxazoline) hydrogel layers on different substrates

Autoři

ŠRÁMKOVÁ Petra KUČKA Jan KRONEKOVÁ Zuzana LOBAZ Volodymyr ŠLOUF Miroslav MIČUŠÍK Matej ŠEPITKA Josef KLEINOVÁ Angela CHORVÁT Dušan MATEÁŠIK Anton HRUBÝ Martin KRONEK Juraj

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Applied Surface Science
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0169433223007389?via%3Dihub
Doi http://dx.doi.org/10.1016/j.apsusc.2023.157061
Klíčová slova Poly[(2-methyl-2-oxazoline)-co-(2-(3-butenyl)- 2-oxazoline)]; Hydrogel coating; Electron beam radiation; Crosslinking; Non-biofouling properties; Mechanical properties
Popis Uncontrolled accumulation of proteins and cells on implantable materials often leads to failure of their performance in vivo. The idea presented in this paper is the use of electron beam irradiation as a widely applicable, cost-effective, and defined method to produce non-biofouling hydrogel coatings to improve the biocompatibility and in vivo performance of implantable materials. Statistical copolymers poly[2-methyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline]s were deposited on different substrates and irradiated with beta radiation of different radiation doses (2–100 kGy). In the bulk state experiments, we found that the higher content of crosslinkable 3-butenyl units and a higher radiation dose resulted in more efficient crosslinking. Similarly, the irradiation of coatings demonstrated the high impact of the concentration of 3-butenyl units on crosslinking efficiency. Accordingly, the concentration of crosslinkable double bonds in the copolymer is crucial for the stability and homogeneity of the formed hydrogel layer. Stable and uniform hydrogel layers with thicknesses in the micrometer range were prepared from a 5 wt% copolymer solution. Depending on the preparation conditions, the hydrogel layers showed excellent non-biofouling properties with a low number of adherent cells. In addition, stiffness was dependent on the degree of crosslinking, and can thus be tailored for specific application in living tissue.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info