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Role of genetics in the development of cardiac allograft vasculopathy

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MAYEROVA Lucie CHALOUPKA Anna WOHLFAHRT Peter HUBACEK Jaroslav Alois BEDANOVA Helena CHEN Zhi KAUTZNER Josef MELENOVSKY Vojtech MALEK Ivan TOMASEK Ales OZÁBALOVÁ Eva KREJČÍ Jan KOVARNIK Tomas SONKA Milan PAZDERNIK Michal

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Bratislava Medical Journal - Bratislavské lekárske listy
Fakulta / Pracoviště MU

Lékařská fakulta

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Doi http://dx.doi.org/10.4149/BLL_2023_031
Klíčová slova cardiac allograft vasculopathy; optical coherence tomography; vascular endothelial growth factor A; intimal thickening; genetic polymorphism
Popis BACKGROUND: The association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options.METHODS: This prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography (OCT) performed 1 month and 12 months after heart transplantation (HTx).RESULTS: During the first post-HTx year, the mean intima thickness (IT) increased by 24.0 +/- 34.2 mu m (p < 0.001) and lumen area decreased by -0.9 +/- 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added.CONCLUSION: Results of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk
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