Informace o publikaci
Evaluation of potentiation of anti-PD-L1 treatment using in vitro models
| Autoři | |
|---|---|
| Rok publikování | 2025 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Immunotherapy has become one of the most important approaches to cancer treatment. Inhibition of immune system checkpoints, specifically targeting programmed cell death protein and ligand (PD-1, PD-L1), is a key strategy in cancer immunotherapy. Anti-PD-L1 therapy, which blocks the interaction between PD-L1 on tumor cells and PD-1 on T-lymphocytes, can restore immune activity and promote tumor regression. Despite significant clinical success in several cancers, including non-small cell lung cancer, the therapeutic efficacy of anti-PD-L1 therapy remains limited in a subgroup of patients. Therefore, potential strategies to enhance therapeutic response are currently under investigation. Our study focuses on evaluating potentiation of anti-PD-L1 therapy using in vitro models. Namely, two types of co-culture models of activated T-lymphocytes, PD-L1-expressing tumor cell lines and anti-PD-L1 antitumor immunotherapy representative were developed. Their functionality was verified using salicylanilide derivatives. Our co-culture models are of great importance for the study of potentiation of antitumor immunotherapy in vitro. |
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