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Acute and chronic methamphetamine effects on agonistic behaviour in mice

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NOVÁKOVÁ Jana VINKLEROVÁ Jana ŠULCOVÁ Alexandra

Rok publikování 2002
Druh Článek ve sborníku
Konference PROGRAMME AND ABSTRACTS of EuroConference MODELING ADDICTION: How closely do genetic, neurochemical, electrophysiological and behavioral experimental models predict human patterns of abuse and dependence
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Farmakologie a lékárnická chemie
Klíčová slova methamphetamine; agonistic behaviour; mice
Popis There is evidence that methamphetamine (MET) increases spontaneous locomotor activity in both, humans and animals. The presnt study investigated MET effects on the full repertoire of agonistic behavioural acts including sociable, defensive-escape, aggressive, and locomotor activities in singly-housed male mice in paired interactions with non-aggressive group-housed partners. MET in our experiments elicited significant inhibition of aggressivity and stimulatory influence on locomotor behaviour, results resembling those of some earlier studies.
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