Informace o publikaci
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups
| Autoři | |
|---|---|
| Rok publikování | 2000 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Biological Inorganic Chemistry |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm |
| Obor | Biofyzika |
| Klíčová slova | DNA;cisplatin; transplatin; cross-link; dimethyl sulfate |
| Popis | DNA binding studies of antitumor effective trans-platinum complexes with planar ligands have shown that they form much higher amount of interstrand cross-links than cisplatin. Interstrand cross-linking are formally equivalent to that of cisplatin but different from their direct ineffective analog, transplatin. This result shows that a simple chemical modification of the structure of inactive compound alters its DNA binding site into an addduct of active drug. |