Informace o publikaci
Computational Study of MutH Recognition and Catalysis
| Autoři | |
|---|---|
| Rok publikování | 2009 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | MutH enzyme participates in methyl-directed DNA repair together with two other enzymes MutS and MutL. Their joint choreography is conceptually known but a lot of details are still elusive. We aim to resolve to two challenging questions related to the recognition and catalytic activity of MutH by utilizing computational techniques. 1) How a single methyl group attached to a far-lying adenine base from the active site can determine the activity of MutH? 2) Is Lys-77 residue serves to couple recognition to catalysis? |
| Související projekty: |