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Chronic treatment with haloperidol changes expression of sigma-1 receptor in rat heart.

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Název česky Chronická léčba haloperidolem mění expresi sigma-1 receptoru v srdci potkana.
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FIALOVÁ Kateřina HUDECOVÁ Soňa SEDLÁKOVÁ Barbora KRIŽANOVÁ Olga NOVÁKOVÁ Marie

Rok publikování 2010
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Popis The effects of sigma receptor ligand haloperidol on expression of sigma-1 receptor after three weeks treatment with this drug were studied in individual parts of the heart - both atria and ventricles. The samples were stored at -80C until PCR specific for the sigma-1 receptor was carried out. Cycloidin was used as a housekeeper gene control for semi-quantitative evaluation of PCR. All PCR products were analyzed on 2% agarose gels. Intensity of individual bands was evaluated by measuring the optical density per mm2 and compared relative to CYCLO mRNA.
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