Informace o publikaci

Multimodal Oncological Therapy Comprising Stents, Brachytherapy and Regional Chemotherapy for Cholangiocarcinoma

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ANDRAŠINA Tomáš VÁLEK Vlastimil PÁNEK Jiří KALA Zdeněk KISS Igor TUČEK Štěpán ŠLAMPA Pavel

Rok publikování 2010
Druh Článek v odborném periodiku
Časopis / Zdroj Gut and Liver
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.5009/gnl.2010.4.S1.S82
Obor Ostatní lékařské obory
Klíčová slova Cholangiocarcinoma; Brachytherapy; Infusions; Intra-arterial; Stents
Popis BACKGROUND/AIMS: To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. In total, 78 metal self-expandable stents were placed. Hilar involvement with mass-forming and periductal infiltrating types of CC (84%) was predominant. The average number of percutaneous interventional procedures was 11.61 per patient (range, 4-35). The median overall survival from diagnosis of disease for all patients was 13.5 months . The median overall survival times were 25.2 months and 11.5 months in the IA and IV arms, respectively (p<0.05). The 1-, 2-, and 3-year survival rates in the IA and IV arms were 88.2%, 52.9%, and 10.1% and 43.5%, 25.4, and 0%, respectively.CONCLUSIONS: We could reach acceptable prognosis in patients with unresectable CC using complex tailored oncological therapy. However, the main limitations of prolonging survival are performance status, patient compliance and the maintaining of biliary tract patency.

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