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Inhibition of topoisomerase IIa: Novel function of wedelolactone

Název česky Inhibice topoizomerázy IIa: nová funkce wedelolaktonu
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BENEŠ Petr KNOPFOVÁ Lucia TRČKA Filip NEMAJEROVÁ Alice PINHEIRO Diana SOUČEK Karel FOJTA Miroslav ŠMARDA Jan

Rok publikování 2011
Druh Článek v odborném periodiku
Časopis / Zdroj Cancer Letters
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.sciencedirect.com/science/article/pii/S0304383511000127
Doi http://dx.doi.org/10.1016/j.canlet.2011.01.002
Obor Genetika a molekulární biologie
Klíčová slova Apoptosis; DNA damage; Proliferation; Topoisomerase; Wedelolactone
Popis The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFkB transcription factor and/or androgen receptors. We found that wedelolactone suppressed growth and induced apoptosis of androgen receptor-negative MDA-MB-231 breast cancer cells at concentrations that did not inhibit the NFkB activity. The cells responded to wedelolactone by the S and G2/M phase cell cycle arrest and induction of the DNA damage signaling. Wedelolactone interacted with dsDNA and inhibited the activity of DNA topoisomerase IIa. We conclude that wedelolactone can act as growth suppressor independently of NFkB and androgen receptors.
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