Does WOQ-9 help to recognize symptoms of non-motor wearing-off in Parkinson’s disease?

Autoři BAREŠ Martin REKTOROVÁ Irena — JECH Robert — FARNÍKOVÁ Kateřina — ROTH Jan — RŮŽIČKA Evžen — KAŇOVSKÝ Petr — REKTOR Ivan PAVLÍK Tomáš — UHLÍŘOVÁ Leona — VYDLÁK Jaroslav
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Citace BAREŠ, Martin, Irena REKTOROVÁ, Robert JECH, Kateřina FARNÍKOVÁ, Jan ROTH, Evžen RŮŽIČKA, Petr KAŇOVSKÝ, Ivan REKTOR, Tomáš PAVLÍK, Leona UHLÍŘOVÁ a Jaroslav VYDLÁK. Does WOQ-9 help to recognize symptoms of non-motor wearing-off in Parkinson’s disease? Journal of Neural Transmission, 2012, roč. 119, č. 3, s. 373–380. ISSN 0300-9564. doi:10.1007/s00702-011-0683-9.
Originální jazyk angličtina
Obor Neurologie, neurochirurgie, neurovědy
Doi http://dx.doi.org/10.1007/s00702-011-0683-9
Klíčová slova Wearing-off; Parkinson’s disease; Levodopa; WOQ-9; Epidemiology

EWO (Epidemiology of Wearing-Off symptoms among the population of Parkinson’s disease (PD) patients on L-DOPA) is a multicentric, non-interventional, epidemiological and exploratory trial, focused on patients with PD who are treated with L-DOPA. The primary objective is the estimation of wearing-off symptoms (based on WOQ-9 questionnaire and assessment by neurologists) among PD patients who are treated with L-DOPA. From September 30, 2007 to June 30, 2008 altogether 563 valid records of PD patients were collected in movement disorders centers (Level A and Level B centers). Wearing-off symptoms were observed in 66.7% of PD patients (neurologists’ assessment) and in 90.6% of PD patients (WOQ-9 questionnaire). The biggest discrepancy was found in PD patients treated with L-DOPA for 0–2 years. The probability of detecting wearing-off by the neurologists strongly correlated with the highest number of positive responses in the WOQ-9 marked by PD patients. There was significant difference in the diagnosis of wearing-off between Level A centers (77.7%) and Level B centers (62.0%). When motor and non-motor symptoms in the WOQ-9 were considered, the difference between neurologists came from the detection of non-motor symptoms (lower in the Level B centers). The neurologists’ assessment of wearing-off symptoms and PD patients’ subjective evaluation of the WOQ-9 is based on the experience of the neurologist and on the detection of the non-motor symptoms of wearing-off. Careful explanation of the WOQ-9 questionnaire and improved awareness of the non-motor symptoms of wearing-off is strongly suggested.

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