Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

Autoři FALTEJSKOVÁ Petra BEŠŠE Andrej ŠEVČÍKOVÁ Sabina KUBICZKOVÁ Lenka SVOBODA Marek ŠMARDA Jan KISS Igor VYZULA Rostislav SLABÝ Ondřej
Druh Článek v odborném periodiku
Citace FALTEJSKOVÁ, Petra, Andrej BEŠŠE, Sabina ŠEVČÍKOVÁ, Lenka KUBICZKOVÁ, Marek SVOBODA, Jan ŠMARDA, Igor KISS, Rostislav VYZULA a Ondřej SLABÝ. Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells. International Journal of Colorectal Disease, New York: Springer, 2012, roč. 27, č. 11, s. 1401-1408. ISSN 0179-1958. doi:10.1007/s00384-012-1461-3.
Originální jazyk angličtina
Obor Onkologie a hematologie
WWW http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
Doi http://dx.doi.org/10.1007/s00384-012-1461-3
Klíčová slova miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration

MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.

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