Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer

Autoři ŠÁNA Jiří HANKEOVÁ Simona SVOBODA Marek KISS Igor VYZULA Rostislav SLABÝ Ondřej
Druh Článek v odborném periodiku
Citace ŠÁNA, Jiří, Simona HANKEOVÁ, Marek SVOBODA, Igor KISS, Rostislav VYZULA a Ondřej SLABÝ. Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer. Oncology, Basel: Karger, 2012, roč. 82, č. 2, s. 114-118. ISSN 0030-2414. doi:10.1159/000336479.
Originální jazyk angličtina
Obor Onkologie a hematologie
WWW http://www.karger.com/Article/Fulltext/336479
Doi http://dx.doi.org/10.1159/000336479
Klíčová slova Colorectal cancer; Non-coding RNAs; Transcribed ultraconserved regions; uc.73; uc.388

The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequenc es longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.

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