Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 312
2019
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Atomic Force Microscopy (AFM) for Bio Applications
Rok: 2019, druh: Uspořádání workshopu
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Bambusuril analogs based on alternating glycoluril and xylylene units
Beilstein journal of organic chemistry, rok: 2019, ročník: 15, vydání: June, DOI
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Bifurcated hydrogen bonds in platinum(II) complexes with phosphinoamine ligands
Polyhedron, rok: 2019, ročník: 170, vydání: 15 September 2019, DOI
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Business Research Forum 2019 - CTT MUNI
Rok: 2019, druh: Popularizační texty
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Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies
Frontiers in Immunology, rok: 2019, ročník: 10, vydání: AUG, DOI
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Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation
Scientific reports, rok: 2019, ročník: 9, vydání: 1660, DOI
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Click-conjugated photon-upconversion nanoparticles in an immunoassay for honeybee pathogen Melissococcus plutonius
Nanoscale, rok: 2019, ročník: 11, vydání: 17, DOI
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Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains
Scientific reports, rok: 2019, ročník: 9, vydání: JUL 31 2019, DOI
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Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Molecular and Cellurar Proteomic, rok: 2019, ročník: 18, vydání: 2, DOI
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Comparative Electrochemical and Spectroscopic Studies of I-motif forming DNA Nonamers
Electroanalysis, rok: 2019, ročník: 31, vydání: 10, DOI