Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 322
2023
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Competing and directing interactions in new phosphoramide/thiophosphoramide structures: energy considerations and evidence for CHMIDLINE HORIZONTAL ELLIPSISHC contacts and aliphatic-aromatic stacking
CrystEngComm, rok: 2023, ročník: 25, vydání: 17, DOI
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Convergent Assembly of the Tricyclic Labdane Core Enables Synthesis of Diverse Forskolin-like Molecules
Angewandte Chemie International Edition, rok: 2023, ročník: 62, vydání: 1, DOI
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Copper Phosphinate Complexes as Molecular Precursors for Ethanol Dehydrogenation Catalysts
Inorganic Chemistry, rok: 2023, ročník: 62, vydání: 49, DOI
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Corynebacterium antarcticum sp. nov., Corynebacterium marambiense sp. nov., Corynebacterium meridianum sp. nov., and Corynebacterium pygosceleis sp. nov., isolated from Adélie penguins (Pygoscelis adeliae)
Systematic and Applied Microbiology, rok: 2023, ročník: 46, vydání: 1, DOI
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Detection and characterization of individual Au nanoparticles using SubAP LDI MSI
Rok: 2023, druh: Další prezentace na konferencích
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Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry
Journal of the American Society for Mass Spectrometry, rok: 2023, ročník: 34, vydání: 7, DOI
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Digital and Analog Detection of SARS-CoV-2 Nucleocapsid Protein via an Upconversion-Linked Immunosorbent Assay
Analytical Chemistry, rok: 2023, ročník: 95, vydání: 10, DOI
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DNA i-motif formation at neutral pH is driven by kinetic partitioning
Nucleic Acids Research, rok: 2023, ročník: 51, vydání: 6, DOI
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Domain 1.1 of σA factor of RNA polymerase from Bacillus subtilis beyond its major state conformation
Rok: 2023, druh: Konferenční abstrakty
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Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate
Molecular Neurodegeneration, rok: 2023, ročník: 18, vydání: 1, DOI