Informace o publikaci

Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages

Autoři

VARGA Marian ZOUHAROVÁ Monika PANTŮČEK Roman MOŠA Marek DOŠKAŘ Jiří

Rok publikování 2014
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Popis The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and inovative antimicrobial strategies. One of them is phage therapy that represents a promising alternative to the use of antibiotics for combating bacterial infections. Some strains, however, are resistant to therapeutic bacteriophages, which may decrease the effectivity of phage-based drugs. In our study, we analyzed causes responsible for this resistance, mainly: (i) efficacy of phage adsorption to bacterial cells; (ii) interference with the products of the prophage-borne genes in lysogenic strains; and (iii) effect of CRISPR-Cas elements.
Související projekty: