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B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

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ŘIHÁČEK Michal BIENERTOVÁ VAŠKŮ Julie VALÍK Dalibor ŠTĚRBA Jaroslav PILÁTOVÁ Kateřina ZDRAŽILOVÁ DUBSKÁ Lenka

Druh Článek v odborném periodiku
Časopis / Zdroj Biomed Research International
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://downloads.hindawi.com/journals/bmri/aa/792187.pdf
Doi http://dx.doi.org/10.1155/2015/792187
Obor Biotechnologie a bionika
Klíčová slova adipocytokine; B cell activating factor; B cell activating factor receptor; estrogen; immunoglobulin enhancer binding protein; insulin receptor; interferon
Popis B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF antibody, belimumab, for the therapy of systemic lupus erythematosus. Concomitantly, the role of BAFF in cancer has been a subject of research since its discovery. Here we review BAFF as a biomarker of malignant disease activity and prognostic factor in B-cell derived malignancies such as multiple myeloma. Moreover, anti-BAFF therapy seems to be a promising approach in treatment of B-cell derived leukemias/lymphomas. In nonhematologic solid tumors, BAFF may contribute to cancer progression by mechanisms both dependent on and independent of BAFF's proinflammatory role. We also describe ongoing research into the pathophysiological link between BAFF and cancer-related cachexia. BAFF has been shown to contribute to inflammation and insulin resistance which are known to worsen cancer cachexia syndrome. Taking all the above together, BAFF is emerging as a biomarker of several malignancies and a possible hallmark of cancer cachexia.
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