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Resting heart rate does not predict cardiovascular and renal outcomes in type 2 diabetic patients

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BARTÁKOVÁ Vendula KLIMEŠOVÁ Linda KIANIČKOVÁ Katarína DVOŘÁKOVÁ Veronika MALÚŠKOVÁ Denisa ŘEHOŘOVÁ Jitka SVOJANOVSKÝ Jan OLŠOVSKÝ Jindřich BĚLOBRÁDKOVÁ Jana KAŇKOVÁ Kateřina

Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Diabetes Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.hindawi.com/journals/jdr/2016/6726492/
Doi http://dx.doi.org/10.1155/2016/6726492
Obor Endokrinologie, diabetologie, metabolismus, výživa
Klíčová slova Diabetic kidney disease
Popis Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 patients at baseline, DKD (glomerular filtration rate 60ml/min or proteinuria) was present in 328 at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss more than3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses significant differences in the cumulative incidence of the studied outcomes, i.e. progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event and all-cause mortality, between RHR 65 (arbitrary cut-off) or 75 (median) bpm were not found. We did not ascertained predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in the Czech Republic.
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