Informace o publikaci

Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation

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SÁNDOR Roman MIDLIK Adam ŠEBRLOVÁ Kristýna DOVRTĚLOVÁ Gabriela NOSKOVÁ Kristýna JUŘICA Jan SLANINOVÁ Iva TÁBORSKÁ Eva PEŠ Ondřej

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Pharmaceutical and Biomedical Analysis
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.sciencedirect.com/science/article/pii/S0731708516300255
Doi http://dx.doi.org/10.1016/j.jpba.2016.01.024
Obor Biochemie
Klíčová slova benzophenanthridines; metabolites; rat liver microsomes; mass spectrometry; isolation
Popis Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown. Reactions involved in transformation include single and/or double O-demethylation, demethylenation, reduction, and hydroxylation. Two metabolites, when isolated, purified and tested for toxicity, were found to be less toxic than the original compounds.
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