Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication

• Autoři: KLUČKA Jozef; JUŘENČÁK Tomáš; KOSINOVÁ Martina; ŠTOURAČ Petr; KRATOCHVÍL Milan; SEDLÁČKOVÁ Yvona; NAVRÁTIL Tomáš; PELCLOVÁ Daniela; JABANDŽIEV Petr
• Rok publikování: 2019
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Monatshefte fur Chemie
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: http://dx.doi.org/10.1007/s00706-019-02423-5
• Doi: http://dx.doi.org/10.1007/s00706-019-02423-5
• Klíčová slova: Antipsychotic drug intoxication; Life-threatening arrhythmia; Lipid resuscitation; Paediatric patient
• Popis: We present a case of the acute intoxication of a 17-year-old patient after ingestion of 6 g of quetiapine in combination with 1 g of lamotrigine. Due to the severe tachycardia, hypertension, and prolonged QTc without improvement after standard treatment, the patient was treated with Intralipid 20% intravenous infusion recommended by the Toxicologic Information Centre. After lipid infusion, the QTc rapidly normalised and tachycardia resolved to sinus rhythm. The patient was transferred to psychiatry intensive care on the third day after admission. [GRAPHICS] .

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