Informace o publikaci

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

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PEKAŘÍK Vladimír KUDLIČKOVÁ PEŠKOVÁ Marie DUBEN Jakub REMES Marek HEGER Zbynek

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Scientific reports
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.nature.com/articles/s41598-020-69336-w.pdf
Doi http://dx.doi.org/10.1038/s41598-020-69336-w
Klíčová slova Direct fluorogenic detection; palladium and platinum organometallic complexes; polyacrylamide gels
Popis Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.
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