Informace o publikaci

Are we approaching a post-monolithic era?

Autoři

URBAN Jiří

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of separation science
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1002/jssc.201901331
Doi http://dx.doi.org/10.1002/jssc.201901331
Klíčová slova gel porosity; heterogeneity; polymer monoliths; stationary phases
Popis Thirty years after their introduction, monolithic stationary phases are an important member of chromatographic phases. When compared to conventional particulate materials, the continuous internal structure of both inorganic silica and organic polymer monoliths allows some hydrodynamic and analytical possibilities that are not provided by conventional particulate stationary phases. Polymer-based monolithic stationary phases offer simple preparation and straightforward surface modification, which makes them very versatile materials that are applicable, for example, as chromatographic stationary phases, sample enrichment units, enzymatic reactors, and external trigger-responding materials. On the other hand, current polymer monoliths cannot compete with efficiency provided by superficially porous and sub 2 mu m particles. In this highlight article, I take advantage of the 30th anniversary of their introduction to discuss several concerns related to polymer-based monolithic stationary phases. Particularly, I focus on preparation repeatability, porous properties, swelling of the polymers in organic solvents, column efficiency for small molecules, and heterogeneity of dominant flow-through pores. In the end, I offer three possible approaches on how to overcome drawbacks related to stationary phases heterogeneity to further increase the applicability of polymer-based monolithic stationary phases.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info